重组人IL-11

产品货号：

GS4873

中文名称：

重组人IL-11

英文名称：

Recombinant Human Interleukin-11

产品规格：

2μg|10μg

发货周期：

1～3天

产品价格：

询价

Interleukin-11 (IL-11) is encoded by the IL11 gene and is a member of IL-6 superfamily,distinguished based on their use of the common co-receptor gp130.It is a multifunctional cytokine first isolated from bone marrow-derived stromal cells.IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 Rα subunit and two molecules of the expressed cell signaling β subunit,gp130.The functions of IL-11 are that it directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells,and induces megakaryocyte maturation resulting in increased platelet production.

Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% by SDS-PAGE and HPLC analyses.
Source	Escherichia coli.
Biological Activity	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1ng/mL,corresponding to a specific activity of> 1.0×106 IU/mg.
Formulation	Lyophilized from a 0.2μm filtered concentrated solution in PBS,pH7.4.
Endotoxin	Less than 1 EU/μg of rHuIL-11 as determined by LAL method.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1～1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.Further dilutions should be made in appropriate buffered solutions.
Molecular Weight	Approximately 19.1kDa,a single non-glycosylated polypeptide chain containing 179 amino acids.
AA Sequence	MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

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